Publications

2018-present: Heemskerk lab

• Endogenous FGFs drive ERK-dependent cell fate patterning in 2D human gastruloids
  K Jo, ZY Liu, G Patel, Z Yu, LA Yao, S Teague, C Johnson, J Spence, I Heemskerk
  bioRxiv (2024)
• Extended culture of 2D gastruloids to model human mesoderm development
  B Chen, H Khan, Z Yu, LA Yao, E Freeburne, K Jo, C Johnson, I Heemskerk
  bioRxiv (2024)
• Time-integrated BMP signaling determines fate in a stem cell model for early human development
  S Teague, G Primavera, B Chen, ZY Liu, LA Yao, E Freeburne, H Khan, K Jo, C Johnson, I Heemskerk
  Nature Communications (2024); bioRxiv (2023)
• Mapping morphogenesis and mechanics in embryo models
  ZY Liu, V Trivedi, I Heemskerk
  Nature methods (2023)
• The many dimensions of germline competence
  S Teague, LA Yao, I Heemskerk
  Current Opinion in Cell Biology (2023)
• Spatial Single Cell Analysis of Proteins in 2D Human Gastruloids Using Iterative Immunofluorescence
  E Freeburne, S Teague, H Khan, B Li, S Ding, B Chen, A Helms, I Heemskerk
  Current protocols (2023)
• Stable iPSC-derived NKX2-1⁺ lung bud tip progenitor organoids give rise to airway and alveolar cell types
  RFC Hein, AS Conchola, AS Fine, Z Xiao, T Frum, LK Brastrom, MA Akinwale, CJ Childs, Y-H Tsai, EM Holloway, S Huang, J Mahoney, I Heemskerk, JR Spence
  Development (2022)
• Roadmap for the multiscale coupling of biochemical and mechanical signals during development
  PF Lenne, E Munro, I Heemskerk, A Warmflash, L Bocanegra-Moreno, …
  Physical biology (2021)
• Efficient differentiation of human primordial germ cells through geometric control reveals a key role for Nodal signaling
  K Jo, S Teague, B Chen, HA Khan, E Freeburne, H Li, B Li, J Spence, I Heemskerk
  Elife (2022); bioRxiv (2021)
• Full of potential: Pluripotent stem cells for the systems biology of embryonic patterning
  I Heemskerk
  Developmental Biology (2019)
• Opening the black box: Stem cell–based modeling of human post-implantation development
  K Taniguchi, I Heemskerk, DL Gumucio
  Journal of Cell Biology (2019)

2012 – 2018: Postdoc

• Nodal is a short-range morphogen with activity that spreads through a relay mechanism in human gastruloids
  L Liu, A Nemashkalo, L Rezende, JY Jung, S Chhabra, MC Guerra, I Heemskerk, A Warmflash
  Nature Communications (2022)
• A novel self-organizing embryonic stem cell system reveals signaling logic underlying the patterning of human ectoderm
  G Britton, I Heemskerk, R Hodge, AA Qutub, A Warmflash
  Development (2019);  bioRxiv (2019)
• Rapid changes in morphogen concentration control self-organized patterning in human embryonic stem cells
  I Heemskerk, K Burt, M Miller, S Chhabra, MC Guerra, L Liu, A Warmflash
  eLife 8 (2019); bioRxiv (2017)
• Morphogen and community effects determine cell fates in response to BMP4 signaling in human embryonic stem cells
  A Nemashkalo, A Ruzo, I Heemskerk, A Warmflash
  Development (2017); bioRxiv (2017)
• A synthetic planar cell polarity system reveals localized feedback on Fat4-Ds1 complexes
  O Loza*, I Heemskerk*, N Gordon-Bar, L Amir-Zilberstein, D Sprinzak
  eLife (2017)
• Differential growth triggers mechanical feedback that elevates Hippo signaling
  Y Pan, I Heemskerk, C Ibar, BI Shraiman, KD Irvine
  Proceedings of the National Academy of Sciences (2016)
• Pluripotent stem cells as a model for embryonic patterning: From signaling dynamics to spatial organization in a dish
  I Heemskerk, A Warmflash
  Developmental Dynamics (2016)
• Tissue cartography: compressing bio-image data by dimensional reduction
  I Heemskerk*, SJ Streichan*
  Nature methods (2015)
• Active Tension Network model of epithelial mechanics
  N Noll, M Mani, I Heemskerk, S Streichan, BI Shraiman
  Nature Physics (2017), arXiv:1508.00623 (2015)
• Dynamic clonal analysis based on chronic in vivo imaging allows multiscale quantification of growth in the Drosophila wing disc
  I Heemskerk, T Lecuit, L LeGoff
  Development (2014)

2009 – 2012: PhD (String Theory)

• Perspectives on Bulk Locality in Gauge/Gravity Duality
  I Heemskerk (2012)
  Thesis (is mostly just the papers below, but for the big picture read the introduction)
• Bulk and transhorizon measurements in AdS/CFT
  I Heemskerk, D Marolf, J Polchinski, J Sully
  Journal of High Energy Physics 2012 (10), 1-29
• Construction of bulk fields with gauge redundancy
  I Heemskerk
  Journal of High Energy Physics 2012 (9), 1-13
• Holographic and Wilsonian renormalization groups
  I Heemskerk, J Polchinski
  Journal of High Energy Physics 2011 (6), 1-28
• More holography from conformal field theory
  I Heemskerk, J Sully
  Journal of High Energy Physics 2010 (9), 1-19
• Holography from conformal field theory
  I Heemskerk, J Penedones, J Polchinski, J Sully
  Journal of High Energy Physics 2009 (10), 079