Red cells have differentiated to endodermal fate (Sox17). The graph visualizes a minimal mathematical model for this cell fate decision.
Our goal is to understand how human pluripotent stem cells generate and interpret the chemical and physical signals that allow them to self-organize into spatial structures consisting of multiple cell types in vitro, and, by extension to the embryo, in vivo. By combining quantitative live-cell measurements and engineering tools such as micropatterning with predictive mathematical models we can answer currently intractable questions in developmental and stem cell biology.
email: idse dot heemskerk at gmail dot com.